Are labs included in the Biological Audit fee?

The program fee covers physician time, interpretation, and program design. Lab work, imaging, and advanced omic testing are ordered based on your individual needs and are typically billed separately through the lab or partner facility. We will review expected categories of testing and costs with you before proceeding.

Do you accept insurance for the Biological Audit?

The Biological Audit® is a precision, concierge-level service and is not billed to insurance. Many clients are able to use HSA or FSA funds for eligible expenses, and our team can provide an itemized receipt or documentation upon request for you to submit to your benefits administrator.

Is the Biological Audit a one-time program or an ongoing membership?

The Biological Audit® is a one-time, foundational assessment designed to give you a clear picture of your current biological status and priorities. It can stand alone or serve as the entry point into an ongoing executive or longevity membership for continued monitoring, optimization, and support.

Biological Audit®️ | Advanced Diagnostics & Multi-Omic Precision Medicine

What the Biological Audit Is

The Signature Diagnostic Program Curated by Anil Bajnath, MD

The Biological Audit is the signature diagnostic program created by Anil Bajnath, MD, as a culmination of his life’s work at the intersection of systems biology, precision diagnostics, and evidence based longevity medicine. It brings together the frameworks he teaches at George Washington University, the principles that shaped his academic career, and the clinical insights gained from more than a decade of caring for patients with complex metabolic, inflammatory, and aging related concerns.

Instead of looking at the body through isolated symptoms or single lab panels, the Biological Audit evaluates how your systems behave together — how your metabolism informs your hormones, how your immune activity shapes your aging trajectory, how your gut and mitochondria influence cognition and performance, and how your genes and environment interact over time.

This is not a routine lab review. It is a comprehensive, physician led evaluation that integrates multi omic analysis, biomarkers of aging, and the hallmarks of aging framework to establish a true baseline of your biological status. The goal is clarity — identifying silent risks, hidden dysfunction, early disease patterns, and opportunities for optimization long before symptoms appear.

Each audit is personally overseen by Dr. Bajnath to ensure every data point is interpreted within the context of your unique physiology, history, and goals. This creates a level of precision that goes far beyond conventional approaches, delivering a clear, structured understanding of why you feel the way you do and what it will take to change your trajectory.

The Biological Audit represents the highest expression of our work at the Institute for Human Optimization — a head to toe, molecule to organ assessment designed to help you protect your health, elevate your performance, and make informed decisions about your future.

How the Biological Audit Works

A Structured Framework for Seeing Your Biology Clearly

Systems biology lens that connects organs, pathways, and lived experience
Multi omic analysis spanning genetics, metabolism, inflammation, and hormones
Biomarkers of aging that quantify biological age and trajectory
Hallmarks of aging mapping to identify where aging is accelerated
Biological threat identification across metabolic, cardiovascular, immune, and neurologic domains
Physician interpretation translated into an actionable plan you can follow

Every Biological Audit is designed as a one time deep evaluation that can also serve as the foundation for ongoing optimization and follow up care.

What We Examine

Head to Toe Mapping of Your Biological Systems

In the Biological Audit®️ we move beyond organ-based checklists and isolated lab values. We examine how your systems interact from head to toe and from molecules to organs — how brain, heart, gut, hormones, immune activity, and metabolism work together to shape your current state of health and your trajectory of aging.

Brain and cognition Focus, memory, mood, neuroinflammatory signals.
Cardiometabolic health Blood vessels, lipids, glucose control, inflammation.
Immune and inflammatory balance Cytokines, chronic activation, immune resilience.
Hormonal signaling Thyroid, adrenal, sex hormones affecting energy, mood, and composition.
Gut and microbiome Digestion, barrier integrity, nutrient absorption, microbial ecology.

This is not a complete list — your specific history, goals, and risks determine which systems and modules we emphasize within your Biological Audit®️.

Multi Omic Preview

A Glimpse Into the Multi Omic Intelligence Behind the Biological Audit®️

The Biological Audit®️ integrates multiple layers of biological data to understand how your physiology is functioning at the deepest levels. Below is a preview of some of the omic domains we analyze to uncover the true drivers of your health, performance, and aging.

This list is not exhaustive. Your Biological Audit®️ includes a more comprehensive and personalized multi omic evaluation than what is shown here.

Data layers referenced in the Audit:

Genomics Epigenomics Transcriptomics Proteomics Metabolomics Microbiome Exposome + additional layers

Foundational Layer

🧬 Genomics (DNA)

Your inherited blueprint and how your genetic wiring shapes risk, resilience, and biological potential.

SNP and polygenic risk patterns
Pharmacogenomic signatures
Detox and inflammatory genes

Biological Aging

🧬 Epigenomics

How lifestyle, environment, and exposures have shaped gene expression and biological age over time.

Biological age estimation
DNA methylation patterns
Stress and adaptation signals

Real Time Activity

🧬 Transcriptomics

Real time gene activity that reflects how your cells are communicating, adapting, and responding now.

mRNA expression trends
Cellular stress responses
Immune activation patterns

Signaling Layer

🧪 Proteomics

Protein based signals that reveal inflammation, repair capacity, and nutrient sensing pathways.

Cytokines and inflammatory proteins
Growth and repair factors
Vascular and metabolic proteins

Metabolic Function

⚡ Metabolomics

A biochemical fingerprint of how your mitochondria, detox pathways, and metabolism are performing.

Organic acid profiling
Mitochondrial efficiency markers
Fatty acid and amino acid balance

Gut Ecosystem

🦠 Microbiomics

The composition and behavior of your gut ecosystem and its impact on immunity, metabolism, and mood.

Microbial diversity and balance
Dysbiosis and barrier integrity
Inflammatory and metabolic metabolites

Life Exposures

🌍 Exposomics

The cumulative impact of toxins, pollutants, lifestyle, and stressors on your long term biological load.

Environmental and toxin burden
Stress and sleep related impact
Lifestyle and circadian influences

Clinical Expression

📊 Phenotypomics & Clinical Biomarkers

How your internal biology expresses itself through function, body composition, and high resolution labs.

Body composition and performance metrics
Cardiometabolic and inflammatory markers
Organ function and hormone metabolite data

Biological Threat Mapping

How the Biological Audit Prioritizes What Matters Most

The outcome of the Biological Audit is not just more data. It is a clear map of the biological threats that matter most to your long term health, performance, and aging. We organize your findings into focused domains so you can see exactly where you are stable, where you are starting to compensate, and where intervention is required.

Metabolic and Cardiometabolic Threat

Early changes in glucose control, insulin dynamics, lipids, visceral fat, and vascular inflammation that increase risk for diabetes, cardiovascular disease, and metabolic syndrome.

Inflammatory and Immune Threat

Patterns of chronic, low grade inflammation, immune over activation, or immune exhaustion that influence autoimmunity, infection risk, and the pace of aging.

Cardiovascular and Vascular Threat

Signals related to endothelial health, plaque formation, blood pressure patterns, and microvascular function that shape your long term heart and brain health.

Neurologic and Cognitive Threat

Markers connected to brain energy, neuroinflammation, sleep quality, mood, and cognitive performance that can predict future decline long before symptoms appear.

Hormonal and Stress System Threat

Thyroid, adrenal, and sex hormone patterns, along with stress system load, that impact energy, weight, recovery, mood, and long term resilience.

Aging Trajectory and Resilience

Biomarkers of aging, recovery capacity, and system flexibility that reveal whether you are aging faster, slower, or in alignment with your chronological age.

This threat map becomes the foundation for your personalized strategy — making it clear where to focus first, what to protect, and how to move from compensation to true optimization.

“When we understand your biology at the molecular, cellular, and systems level, we can intervene early, precisely, and meaningfully. That is the future of medicine and the purpose of the Biological Audit®️.”

Anil Bajnath, MD Physician · Systems Biologist · Founder, Institute for Human Optimization

Biological Age & Hallmarks of Aging

Mapping the Hallmarks of Aging That Shape Your Biological Trajectory

The Biological Audit®️ looks beyond chronological age and examines the cellular and molecular processes that drive how you are truly aging. Rather than giving you a single biological age number, we evaluate the twelve recognized hallmarks of aging to see which processes are stable, which are compensated, and which are beginning to accelerate.

This helps us understand not just how old you are, but how you are aging — and where targeted interventions will have the greatest impact.

Hallmarks
of Aging

Each hallmark is mapped to your multi omic and clinical data to identify which aging processes are moving faster, slower, or in alignment with your chronological age.

🧬

Genomic Instability

Signals of DNA damage, repair capacity, and genomic stress that influence long term risk.

⏳

Telomere Attrition

Telomere dynamics and related markers that reflect replicative history and cellular strain.

✴️

Epigenetic Alterations

DNA methylation patterns, biological age estimates, and shifts in gene regulation.

🧪

Loss of Proteostasis

Imbalances in protein folding, clearance, and repair that increase cellular stress.

♻️

Disabled Macroautophagy

Reduced cellular clean up and recycling capacity that impacts longevity and resilience.

📉

Deregulated Nutrient Sensing

Patterns across insulin, IGF, mTOR, AMPK and related pathways that drive metabolic aging.

⚡

Mitochondrial Dysfunction

Energy production, oxidative stress, and mitochondrial reserve capacity across tissues.

🧱

Cellular Senescence

Senescent cell burden and associated signaling that accelerates tissue aging.

🌱

Stem Cell Exhaustion

Regenerative capacity and recovery markers that reflect the ability to repair and rebuild.

📡

Altered Intercellular Communication

Inflammatory and hormonal signaling patterns that affect how systems coordinate with each other.

🔥

Chronic Inflammation

Persistent low grade inflammatory signaling that amplifies risk across multiple organ systems.

🦠

Microbiome Disturbance

Gut ecosystem changes that influence immunity, metabolism, and systemic inflammation.

Learn more about the Hallmarks of Aging on Our Science page →

From Insight to Intervention

From Biological Audit to Precision Action Plan

The Biological Audit®️ is not a report. It is a roadmap. Once we have mapped your biomarkers, multi omic signatures, and hallmarks of aging, we translate those findings into a precise, individualized strategy designed to improve your trajectory of health.

This is where data becomes medicine.

Step 1 · Define Your Biological Priorities

We begin by organizing your data into clear priorities: which molecular processes, organ systems, and aging mechanisms require immediate focus, and which are currently stable or outperforming your chronological age.

Step 2 · Design Your Precision Intervention Strategy

Using your Biological Audit®️ findings, we architect a personalized plan across lifestyle, pharmacology, peptides, regenerative biologics, supplements, and environmental shifts — ranked by clinical impact and feasibility.

Step 3 · Target the Drivers of Your Aging Pattern

Every recommendation is mapped back to the hallmarks and mechanisms most active in your data — mitochondrial efficiency, senescence, inflammation, nutrient sensing, genomic stability, and more.

Step 4 · Implement With Physician-Led Guardrails

You receive structured protocols, dosing guidance, and sequencing with physician oversight so each intervention is implemented safely, intentionally, and in alignment with your biomarkers.

Step 5 · Track, Reassess, and Recalibrate

Your biology is dynamic. We repeat selected testing, monitor key biomarkers, and refine your plan as systems adapt — keeping your trajectory moving toward greater resilience and improved healthspan.

01

Define Your Biological Priorities

Clarify what needs attention now and what is performing above baseline.

02

Design Your Intervention Strategy

Build a personalized framework across lifestyle, pharmacology, and biologics.

03

Target the Drivers of Your Aging Pattern

Link every intervention to the hallmarks accelerating in your data.

04

Implement With Physician-Led Guardrails

Execute with clear protocols, safety parameters, and clinical oversight.

05

Track, Reassess, and Recalibrate

Re-measure and refine as your biology and goals evolve.

Investment

Biological Audit Program Fee

The Biological Audit®️ is a comprehensive, physician-led evaluation that consolidates advanced diagnostics, multi omic analysis, and a precision plan into a single, curated experience.